I'm deep into Roberto Bolano's work and would highly recommend it to those of you who lean a bit closer to the academic side of contemporary lit. I know 2666 is enormous and I'm sure you've heard the buzz about it... in my opinion it is really worth it. Kind of life-changing. Take it slow an you'll be rewarded.
Also, I've started a book-collecting blog, thought I'd plug it here:
http://theoxenofthesun.blogspot.com
take a look and let me know what you think.